[问答题]
Cancer studies have shown that many tumours have
l9u7*quf/nqcp-br ,nx7; ya:2dx adhlr* z(z abnormal patterns of aerobic respiration, showing increased levels of glycolysis and lower levels of oxidative phosphorylation, even in the presence of high oxygen levels. A breast cancer cell line (MDA-MB-231) shows variable protein expression of complex III in the electron
d(dyr ;hxa:*z2 x7lza transport chain compared to normal breast tissue.
1.State the independent variable in this study.
2.Outline the role of the complexes in the electron transport chain.
3.Suggest one advantage and one disadvantage of breast cancer cells using glycolysis to generate ATP rather than oxidative phosphorylation.
4.Predict, with a reason, what would happen to the levels of oxidative phosphorylation in the non-cancerous cells if they were treated with an inhibitor of glycolysis.
5.Explain why non-cancerous breast cancer cells were used as a control in this study.
6.The researchers concluded that downregulation of complex III in breast cancer cells is a cause of breast cancer. Evaluate this conclusion.
7.Outline one measurement that could be taken to determine the activity of Complex III in this study.
